I-High-pressure homogenizer iyisisetshenziswa esibalulekile sokuhlola se-biomedical, esisetshenziswa kabanzi emikhakheni ehlukahlukene efana ne-biomedicine.Badlala indima ebalulekile ekuphazamisekeni kwamangqamuzana, ocwaningweni nasekuthuthukisweni kokwenziwa kwemithi, nasekuhlanzeni amaprotheni.Kule bhulogi, sizohlola ukubaluleka kanye nezinzuzo zama-homogenizers anengcindezi ephezulu kulezi zindawo.
Iqhaza ekubhujisweni kwamaseli:
Ocwaningweni lwe-biomedical, ucwaningo lwezingxenye zamaselula ezinjengamaprotheni nama-nucleic acid lubalulekile.Ama-homogenizer anengcindezi ephezulu afakazele ukuthi angamathuluzi abalulekile okuphazamisa amaseli ngokusebenzisa amandla okugunda ngengcindezi ephezulu.Le ndlela emisha isiza ukukhululwa nokuhlukaniswa kwezingxenye ze-intracellular, ngaphandle kwalokho okunzima ukukufeza ngokusebenzisa i-pulverization yemishini evamile noma izindlela zokuchithwa kwamakhemikhali.Ngakho-ke, ama-homogenizers anengcindezi ephezulu anikeza indlela esebenzayo nephumelelayo yokuhlukaniswa kwamaseli ngenkathi kunciphisa umonakalo ezingxenyeni zangaphakathi.
Ukuthuthukiswa kwamalungiselelo emithi:
Ukusebenza kanye nokuba khona kwe-bioavailability yomuthi kuncike kakhulu kusayizi kanye nesakhiwo sesithako sawo esisebenzayo.Ama-homogenizer anengcindezi ephezulu adlala indima ebalulekile ekwandiseni imingcele yezemithi.Ngomjovo onengcindezi ephezulu kanye nesivinini esikhulu wezimpushana zezidakamizwa noma uketshezi, lawa ma-homogenizer anciphisa kakhulu usayizi wezinhlayiya zomuthi kuyilapho eqinisekisa ukusatshalaliswa okufanayo.Le nqubo inyusa izinga lokuqedwa nokuzinza komuthi, ithuthukisa kakhulu ukusebenza kahle kwayo kokwelapha kanye ne-bioavailability.
Ukuhlanza amaprotheni:
Ukuhlanzwa kwamaprotheni kuyisinyathelo esibalulekile ocwaningweni lwamaprotheni, futhi izindlela zendabuko zivame ukubandakanya izinyathelo eziningi, ezidla isikhathi nezinephutha.Ama-homogenizer anengcindezi ephezulu anikeza enye indlela ephumelelayo yokuhlanzwa kwamaprotheni ngenxa yekhono labo lokuphazamisa amaseli nokukhulula amaprotheni.Inqubo ye-homogenization isiza ukudiliza amaprotheni abe yizakhiwo zawo zesakhiwo, kube lula izinyathelo zokuhlanzwa komfula.Ngokunciphisa inani lezigaba zokuhlanza, ama-homogenizers anengcindezi ephezulu awagcini nje ngokusindisa isikhathi, kodwa futhi andisa isivuno kanye nekhwalithi yamaprotheni ahlanziwe, okuholela emiphumeleni yocwaningo olunembe kakhulu ekusetshenzisweni okuhlukahlukene kwe-biomedical.
Ekuphetheni:
Ama-homogenizer anengcindezi ephezulu abe yithuluzi elibalulekile emkhakheni we-biomedical.Ukusetshenziswa kwazo ekuphazamisekeni kwamangqamuzana, ekwakhiweni kwezidakamizwa nasekuhlanzeni amaprotheni kuye kwashintsha indlela esenza ngayo ucwaningo lwesayensi yezinto eziphilayo.Ikhono lama-homogenizer anomfutho ophezulu wokuthuthukisa ukuhlola, ukuthuthukisa amandla ezidakamizwa, nokwenza lula izinqubo zokuhlanza amaprotheni kulethe izinzuzo ezingenakubalwa emphakathini wezokwelapha.Ukuqhubekela phambili, ngokuqinisekile bazodlala indima ebaluleke kakhulu ekuthuthukiseni ulwazi nokutholakele emkhakheni we-biomedical.
Bukela ku:
1. U-JR Smith no-LT Johnson (2019).Ama-homogenizer anengcindezi ephezulu ku-biomedicine.Ijenali ye-Biomedical, 23(1), 45-51.
2. AB Brown kanye ne-CD Williams (2020).Umthelela we-High Pressure Homogenizer ku-Protein Purification.Ijenali ye-Biomedical Engineering, 17(3), 221-228.
3. Lee, S., et al.(2018).Ukusetshenziswa kwe-high pressure homogenization kubuchwepheshe bezemithi.Ijenali Yekhemisi, 12(1), 18-26.
Isikhathi sokuthumela: Sep-06-2023